Updated on March 10, 2024

Why you should buy CBDA and not CBD

Fact Checked

Key takeaways

  • CBDA is more powerful than CBD.
  • CBDA is 1000 times more active than CBD at reducing nausea and interacting with receptors.
  • CBDA was the first cannabinoid acid to be isolated. It was isolated in 1955.
  • All natural cannabinoids exist as acids in the cannabis plant.
  • CBDA is the original compound produced by the cannabis plant. It is later converted to CBD when the cannabis plant grows old or when the cannabis plant is exposed to harsh environmental conditions such as heat or chemicals.
  • The process of converting CBDA to CBD is known as decarboxylation.
  • Decarboxylation typically occurs when the cannabis plant is exposed to heat, such as during smoking or vaporization.
  • Cannabinoids are created differently. No two cannabinoids are the same.
  • Many researchers believe CBDA could be more effective than CBD for several conditions.
  • CBDA was the most active cannabinoid against COVID-19.
  • CBDA is more easily absorbed in the body than CBD.

There are over 120 cannabinoids identified from the cannabis plant with each cannabinoid offering unique benefits to the human body. Cannabinoids are created differently and in this article, we would look at why you should consider CBDA over CBD.

What is CBDA?

CBDA stands for cannabidiolic acid, which is the acidic precursor to CBD. It is the original compounds formed by the cannabis plant and is abundant in actively growing cannabis plants and flowers. CBDA was first discovered in 1955. It was the first cannabinoid acid to be discovered followed by CBCA which was isolated in 1968.

CBDA is naturally found in the raw cannabis plant, and it can be converted to CBD through a process called decarboxylation. Decarboxylation typically occurs when the cannabis plant is exposed to heat, such as during smoking or vaporization. While both CBDA and CBD are believed to have potential health benefits, research on CBDA is still in its early stages, and more studies are needed to fully understand its properties and effects.

CBDA is available in various forms, including oils, tinctures, capsules, edibles, and topical products, making it accessible for different preferences and needs.

What is CBD?

CBD stands for cannabidiol, which is a natural compound found in the cannabis plant. It is one of over 100 cannabinoids present in cannabis. Unlike its well-known counterpart, THC, CBD is not psychoactive, meaning it does not produce a "high" sensation commonly associated with cannabis use.

CBD interacts with the endocannabinoid system in the human body, which plays a crucial role in regulating various physiological processes, including mood, sleep, appetite, and immune response. As a result, CBD is believed to have potential therapeutic effects and has been studied for its possible benefits in managing conditions such as anxiety, pain, inflammation, epilepsy, and more.

Like CBDA, CBD is available in different forms including oils, tinctures, capsules, edibles, and topical products.

What does research say about CBDA?

Many researchers believe CBDA could be more effective than CBD for several conditions. For instance, a research paper published in 2016 shows that CBDA was found to be 1000 times more active than CBD at reducing acute nausea.

Another group of researchers reported how CBDA was discovered to readily interact with several receptors to produce a more potent anti-inflammatory, analgesic, anxiolytic and antioxidant effect than CBD.

Another research published in 2020 shows that CBDA was more effective at killing breast cancer cells than CBD. Based on their findings, CBDA was able to inhibit the activity of certain enzymes responsible for breast cancer at a lower concentration than CBD.

CBDA was also found as the most active cannabinoids against SARS-COV-2 variants. According to the research report published in 2023, the antiviral activity of cannabinoids isolated from Cannabis sativa L. was assessed in vitro against a panel of SARS-CoV-2 variants, indicating cannabidiolic acid (CBDA) was the most active. 

4 reasons you should buy CBDA and not CBD

  1. Natural vs. synthetic

CBDA products are primarily natural and contain minimal to no synthetic or added ingredients. Since it is often found in small quantities in the cannabis plant, the extraction process targeting CBDA must maintain the plants in their natural forms. In contrast, CBD often undergoes various levels of exposure to harsh extraction procedures, such as the addition of chemicals and heat, which can destroy CBDA. The natural nature of CBDA and its products allows for increased interaction between cannabinoids and receptors. The chemical structure of CBDA enables it to readily engage with endocannabinoid receptors. At Nesas hemp, we believe in the power of organic cannabinoids that is why we ensure every production process from the soil to the packaging use organic products. You can read our article on CBDA vs. CBD for more information.

  1. Lower contamination;

While many companies may claim to offer CBD products, only a select few can genuinely boast of CBDA products. This is because the extraction process is not expensive. Stabilizing CBDA demands a substantial amount of effort, which naturally comes with a cost. The rigorous extraction process, aimed at preserving CBDA and other cannabinoid acids in the hemp plant, also ensures minimal to no presence of toxic contaminants.

  1. Higher activity

CBDA is 1000 times more active than CBD. It can replicate all the therapeutic benefits of CBD and more at a significantly reduced dosage. The presence of an extra functional group (-COOH) on CBDA enables it to readily interact with receptors, providing better therapeutic benefits. This is why scientists discovered that CBDA exhibits enhanced antiviral activity against the SARS-COV-19 variant-2, a superior anti-nausea effect, and a higher potential for combating breast cancer cells.

  1. Higher bioavailability and faster effects:

Research shows that all acidic cannabinoids including CBDA exhibit a higher bioavailability than their neutral counterparts. This higher bioavailability allows CBDA to produce faster effects than CBD. This is why people are most likely to feel faster relief or observe a more noticeable effect after taking CBDA.

Frequently asked questions

What are the effects of CBDA?

CBDA has effects like relieving pain, reducing inflammation, and preventing nausea. It can also lessen seizures, anxiety, and depression in mice.

Does CBDA convert to CBD in the body?

No, CBDA does not convert to CBD in the body. CBDA converts to CBD especially when heated or exposed to air for a very long time.

Is CBDA more powerful than CBD?

Yes, research shows that CBDA is better at stopping the spread of breast cancer in laboratory animals, it was also more effective at reducing nausea, stomach discomfort and nervousness.

Want to Learn More?

  1. Nesas Hemp—the first to receive the Exclusive Tested Safe Seal.
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  5. What Is Ayurveda, And Is It For Me?


  1. Nadal X, Del Río C, Casano S, Palomares B, Ferreiro-Vera C, Navarrete C, Sánchez-Carnerero C, Cantarero I, Bellido ML, Meyer S, Morello G, Appendino G, Muñoz E. Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity. Br J Pharmacol. 2017 Dec;174(23):4263-4276. doi: 10.1111/bph.14019. Epub 2017 Nov 2. PMID: 28853159; PMCID: PMC5731255.
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The content on Nesa's Hemp blog is for educational purposes only. We meticulously research and cite our sources, but advise consulting a professional before making decisions based on our information. We derive our content from reputable studies and publications, but individual circumstances may vary. We cannot guarantee the accuracy or applicability of our content to every situation. Nesa's Hemp blog and its authors are not liable for any loss or inconvenience resulting from reliance on our information. By using our blog, you waive any claims against us regarding the accuracy or completeness of our content.

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