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Updated on July 18, 2023

7 Eye-Opening Facts about the Endocannabinoid System and Hemp Oil

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Hemp oil interplays with your body’s endocannabinoid system (ECS), unlocking a world of fascinating connections and potential.  Imbalances or dysfunction within the ECS have been associated with various health conditions. These include chronic pain, inflammation, mood disorders, and neurodegenerative diseases. But what exactly is the ECS, and why is it so critical for health and well-being? 

Endocannabinoid System and Hemp Oil

7 Eye-Opening Facts about the Endocannabinoid System and Hemp Oil

Continue reading as we explore 7 captivating facts illuminating the intricate relationship between hemp oil and the ECS. In the following sections, we’ll unveil how these two forces intersect and synergize, offering a natural pathway to enhanced well-being and balance. 

1. The ECS was discovered in the 1990s

In the 1990s, a wave of scientific curiosity swept across the field of cannabis and hemp research. Scientists began to uncover the mysteries behind these plants' effects on the human body, and in doing so, they stumbled across a groundbreaking discovery — the ECS.

This revelation highlighted the remarkable interconnectedness of nature, demonstrating how a plant, such as hemp, could unlock the door to an internal system that exists within us all. The discovery of the ECS showcased the intricate dance between humans and the natural world, unveiling a sacred bond that weaves through the fabric of existence.

The ECS's emergence from the shadows not only transformed our understanding of the human body but has also sparked a profound appreciation for the wonders of nature's design, reminding us that we are intrinsically intertwined with the Earth and all its botanical wonders.

2. The ECS is present in all animals

The ECS isn’t exclusive to humans. Rather, it exists in an astonishing array of creatures across the animal kingdom, from sea urchins and leeches to birds, reptiles, and mammals. 

This revelation expands the understanding of the ECS and reinforces the fundamental connection between all living beings.

The fact that the ECS is not exclusive to humans signifies its ancient and essential attributes, serving as a profound reminder that we share a deep attachment with the natural world. 

3. The ECS consists of three main components

The ECS is an incredibly complex network consisting of three key components working in harmony to maintain physiological balance and promote homeostasis. 

Cannabinoid receptors

Currently, scientists recognize two cannabinoid receptors — CB1 and CB2. These receptors serve as the gatekeepers of the ECS, becoming activated by endocannabinoids from the body or phytocannabinoids from hemp oil or cannabis. 

Once triggered, they initiate a cascade of cellular responses, transmitting messages within the body. They influence the release of neurotransmitters in the brain, modulate the immune response, regulate inflammation, and impact other physiological functions. 

By fine-tuning these processes, CB receptors help maintain balance and promote homeostasis, which is the state of equilibrium within the body necessary for optimal health and well-being.


Endocannabinoids, such as anandamide and 2-AG, are naturally occurring compounds produced by the body that bind to cannabinoid receptors. Anandamide, often referred to as the "bliss molecule," promotes a sense of well-being and relaxation. 2-AG, on the other hand, plays a significant role in modulating inflammation and pain perception. 

These endocannabinoids act as messengers, relaying signals throughout the body to initiate cellular responses and maintain physiological balance.


Enzymes within the ECS are responsible for the synthesis and breakdown of endocannabinoids. Fatty acid amide hydrolase (FAAH) is the enzyme that breaks down anandamide, while monoacylglycerol lipase (MAGL) is responsible for breaking down 2-AG once these molecules have performed their purpose. 

4. CB1 and CB2 receptors have distinct locations and functions.

CB1 and CB2 receptors have distinct locations and functions within the body. This differentiation allows them to fulfill specific roles in regulating various processes.

CB1 receptors are predominantly found in the central nervous system (CNS), particularly in regions such as the cerebral cortex, hippocampus, basal ganglia, and cerebellum of the brain. 

These receptors exert significant influence over brain function as by binding with endocannabinoids or external cannabinoids, CB1 receptors modulate the release of neurotransmitters. This affects the communication between neurons and contributes to regulating multiple critical processes. 

Conversely, CB2 receptors are primarily located in peripheral tissues, particularly within the immune system. They’re abundant in immune cells such as macrophages, B cells, T cells, and natural killer cells. CB2 receptors also reside in the spleen, tonsils, and other immune-related organs. 

Activation of CB2 receptors modulates immune cell activity, influencing functions such as immune cell migration, cytokine production, and the release of other inflammatory molecules. 

By regulating the immune response, CB2 receptors help maintain the delicate balance of the immune system and contribute to the modulation of inflammation levels and maintaining immune system balance.

5. The ECS regulates various physiological processes.

The ECS plays a pivotal role in maintaining homeostasis, a state of internal balance, by regulating numerous physiological processes, including:

  • Mood: Through the interaction of endocannabinoids and cannabinoid receptors, the ECS helps modulate the release and uptake of neurotransmitters associated with mood regulation, such as serotonin and dopamine. This regulation contributes to the balance of emotional well-being and mental stability.
  • Appetite: The ECS impacts the regulation of hunger and satiety signals. By affecting the release of appetite-related hormones, the ECS helps maintain a healthy balance of eating patterns and body weight.
  • Pain: When tissue damage or inflammation occurs, the ECS acts as a modulator, reducing excessive pain signaling and promoting pain relief. By interacting with cannabinoid receptors in the nervous system, the ECS helps regulate pain perception, providing a natural mechanism for pain management.
  • Inflammation: Inflammation, a complex immune response that contributes to healing and defending against pathogens, is also under ECS influence. The ECS helps regulate immune cell activity and the release of inflammatory molecules, contributing to fine-tuning the inflammatory response. By modulating inflammation levels, the ECS ensures a balanced immune response and promotes healthy immune function.
  • Sleep: Sleep is a fundamental process necessary for overall well-being. The ECS influences sleep patterns and promotes healthy sleep-wake cycles by interacting with neurotransmitters and brain regions involved in sleep regulation. 
  • Memory: Memory formation and cognition are additional areas where the ECS significantly impacts. Through its involvement in neurotransmitter release, synaptic plasticity, and neurogenesis, the ECS contributes to regulating memory and cognitive processes, such as learning, information retention, and overall cognitive function.

The ECS operates through a feedback loop system, continuously monitoring the body's internal environment, and assessing any imbalances or deviations from the desired state. It then triggers appropriate responses to restore balance, serving as a vital conductor, delicately regulating a wide range of physiological processes to support overall well-being and optimal functioning of the body and mind. 

6. Hemp oil cannabinoids interact with the ECS

High-quality hemp oil contains a rich array of cannabinoids that interact with the ECS. Among these cannabinoids are CBD (cannabidiol), its parent compound CBDa (cannabidiolic acid), and THC (tetrahydrocannabinol).

As you consume hemp oil, its rich profile of cannabinoids interacts with your body’s cannabinoid receptors, much like endocannabinoids do. This interaction leads to changes in receptor activity, bringing about a cascade of effects.

THC, the primary intoxicating compound in cannabis, has a high affinity for CB1 receptors in the CNS. When it interacts with the receptors, it produces the characteristic effects associated with marijuana consumption. 

Beyond its psychoactive properties, THC also has the potential to modulate pain perception, reduce nausea and vomiting, stimulate appetite, and manage certain neurological conditions.

CBD interacts with both CB1 and CB2 receptors and has a more complex mechanism of action. It may also modulate the activity of other receptors, including serotonin and vanilloid receptors, which contribute to its broad therapeutic effects. 

Beyond THC and CBD, hemp oil contains other cannabinoids, such as CBG (cannabigerol), CBC (cannabichromene), and CBN (cannabinol), each with its unique properties and potential benefits. These cannabinoids interact with the ECS, although researchers are still exploring their specific mechanisms and effects.

7. Your ECS benefits from high-quality hemp oil

Your ECS flourishes when nourished with high-quality hemp oil. By choosing premium organic hemp extract, like Nesas Hemp, you provide your ECS with the optimal support it needs to function at its best and maintain wellness.

Our high-quality hemp oil is carefully crafted from organically grown, lovingly produced hemp plants, ensuring the final product is free from harmful pesticides, herbicides, and other dangerous contaminants. This dedication to purity and sustainability preserves the natural integrity of the hemp plant, allowing the cannabinoids and other beneficial compounds to be extracted in their most potent and bioavailable forms.

Moreover, our premium hemp oil undergoes rigorous testing to ensure its potency, purity, and consistency. This commitment to quality assurance guarantees that you receive a reliable and trustworthy product that delivers the desired benefits to your ECS.

By choosing Nesas Hemp as your source of high-quality hemp oil, you can rest assured that you’re providing your ECS with the finest nourishment it deserves. The natural richness of Nesas Hemp oil serves as a catalyst for unlocking your body's innate healing potential and nurturing your connection with the natural world.

So why not experience the difference that premium organic hemp extract can make and embrace the vitality and balance it brings to your life?

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