Updated on March 24, 2024

CBD and testosterone

Fact Checked

Key takeaways

  • Both CB1 (cannabinoid receptor type 1) and CB2 (cannabinoid receptor type 2) receptors, which are part of the endocannabinoid system, are found in the male reproductive organs, including the testes and sperm cells.
  • The endocannabinoid system appears to be involved in the regulation of spermatogenesis, the process of sperm cell development.
  • Research on the possible roles of CBD on testosterone levels is quite unclear. While some researchers believe chronic use of CBD may lead to reduced testosterone levels, other research findings believe moderate use of CBD may improve sexual performance and address possible causes of low testosterone levels like inflammation and chronic stress.
  • More research will be needed to understand how CBD dosage may affect testosterone levels.

Extensive research has focused on CBD and its impact on hormonal balance, particularly due to the role of the Endocannabinoid System (ECS). This article explores the potential benefits of CBD for testosterone levels.

What is testosterone?

Testosterone is a hormone that belongs to a class of male sex hormones called androgens. It plays a crucial role in the development of male reproductive tissues and the maintenance of male characteristics. While it is primarily associated with males, females also produce small amounts of testosterone.

Functions of testosterone

  1. Development of Male Reproductive Organs: Testosterone is vital for the development of the male reproductive system, including the testes and prostate.
  2. Secondary Sexual Characteristics: During puberty, testosterone contributes to the development of secondary sexual characteristics in males, such as increased muscle mass, body hair growth, deepening of the voice, and the growth of the Adam's apple.
  3. Sperm Production: Testosterone is necessary for the production of sperm in the testes.
  4. Bone Density: It plays a role in maintaining bone density and muscle mass.
  5. Libido: Testosterone influences sexual desire or libido.
  6. Mood and Energy: Testosterone levels can impact mood, energy levels, and overall well-being.

Factors that affect testosterone levels

Testosterone levels typically decrease with age, and low levels may be associated with various health conditions. Medical conditions such as hypogonadism can lead to lower-than-normal testosterone levels, requiring medical attention and, in some cases, hormone replacement therapy.

Can CBD affect levels of testosterone?

Research on the possible roles of CBD on testosterone levels is quite unclear. While relationship between the endocannabinoid system and CBD may be vital for controlling the endocannabinoid’s system effect on testosterone levels, chronic cannabis uses have been associated with alteration in reproductive hormone levels.

Report from a 2019 study shows that Continuous exposure to cannabinoids in male rats and humans has been linked to lower sperm count, decreased testosterone levels, and reduced luteinizing hormone (LH) levels. For females, ongoing exposure to cannabinoids can delay sexual maturation, disrupt the menstrual cycle, hinder ovarian follicular maturation, and lower LH and sex hormone levels.

Another study from 2020 shows that chronic use of CBD had negative effect on the male reproductive system including hormones like testosterone.

A more recent study in 2023 reported otherwise. Research findings from the 2023 research shows that using CBD without a doctor's prescription didn't show more cases of high or low testosterone levels in men. Also, CBD use was linked to lower levels of a hormone related to diabetes and a lower chance of having low testosterone in older men compared to what's normal for their age.

Contrary to research findings, some individuals who have used CBD believed it reduced their stress and inflammation thus improving testosterone levels and sexual performance. It is also pertinent to note that high levels of inflammation and stress can lead to reduced testosterone production.

Relationship between testosterone and endocannabinoid system

The relationship between testosterone and the endocannabinoid system (ECS) is complex and not fully understood, but there is evidence suggesting that the ECS may play a role in regulating testosterone levels. The ECS is a signaling system in the body involved in maintaining homeostasis and regulating various physiological processes.

Here are some key points regarding the relationship between testosterone and the endocannabinoid system:

  1. Receptor Presence: Both CB1 (cannabinoid receptor type 1) and CB2 (cannabinoid receptor type 2) receptors, which are part of the endocannabinoid system, are found in the male reproductive organs, including the testes and sperm cells.
  2. Spermatogenesis: The endocannabinoid system appears to be involved in the regulation of spermatogenesis, the process of sperm cell development. CB1 receptors are present in the testes, and studies suggest that endocannabinoids may influence the various stages of spermatogenesis.
  3. Feedback Mechanism: The ECS may play a role in a feedback mechanism that regulates the release of hormones, including testosterone. Some studies have suggested that cannabinoids can influence the hypothalamic-pituitary-gonadal (HPG) axis, which is a key system in the regulation of sex hormones.

Frequently asked questions

What does CBD do for males?

While research hints that CBD may indirectly boost sexual performance by alleviating anxiety, enhancing mood, and reducing high blood pressure, these factors collectively contribute to improved erectile function.

Does CBD help men last longer in bed?

As of now, there is no reliable scientific evidence to support the claim that CBD helps men last longer in bed or treats erectile dysfunction. Current research does not confirm the effectiveness of CBD or cannabis in improving sexual performance or addressing issues like ED.

Is CBD good for sperm?

A 2021 study in Therapeutic Advances in Urology involving 409 men undergoing infertility evaluation revealed that CBD, particularly in past and current marijuana users, affected sperm shape and function. The study also noted a reduction in semen volume and sperm count associated with marijuana use.

Want to Learn More?

  1. How To Recover From Burnout in 8 Ways
  2. Is CBD Oil Addictive? Find Out Now
  3. How To Change Your Mood Now
  4. Hemp Leaf And Marijuana: How They Differ
  5. Can CBD Oil Help With Candida?


Walker, O.S., Holloway, A.C. & Raha, S. The role of the endocannabinoid system in female reproductive tissues. J Ovarian Res 12, 3 (2019). https://doi.org/10.1186/s13048-018-0478-9

Kaufmann, R., Bozer, A. H., Kube Jotte, A. R., & Aqua, K. (2023). The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function. Medical Cannabis and Cannabinoids, 6(1), 32-40. https://doi.org/10.1159/000529677

Carvalho RK, Andersen ML, Mazaro-Costa R. The effects of cannabidiol on male reproductive system: A literature review. J Appl Toxicol. 2020 Jan;40(1):132-150. doi: 10.1002/jat.3831. Epub 2019 Jul 17. PMID: 31313338.

Hehemann MC, Raheem OA, Rajanahally S, Holt S, Chen T, Fustok JN, Song K, Rylander H, Chow E, Ostrowski KA, Muller CH, Walsh TJ. Evaluation of the impact of marijuana use on semen quality: a prospective analysis. Ther Adv Urol. 2021 Jul 20;13:17562872211032484. doi: 10.1177/17562872211032484. PMID: 34367341; PMCID: PMC8299873.

da Silva J, Dochez-Arnault J, Desdoits-Lethimonier C, Dejucq-Rainsford N, Gely-Pernot A. The Acute Exposure of Human Adult Testis Tissue to Cannabinoids THC and CBD Does Not Impact Testosterone Production Nor Germ Cell Lineage. World J Mens Health. 2023 Oct;41(4):928-939. https://doi.org/10.5534/wjmh.220210

The content on Nesa's Hemp blog is for educational purposes only. We meticulously research and cite our sources, but advise consulting a professional before making decisions based on our information. We derive our content from reputable studies and publications, but individual circumstances may vary. We cannot guarantee the accuracy or applicability of our content to every situation. Nesa's Hemp blog and its authors are not liable for any loss or inconvenience resulting from reliance on our information. By using our blog, you waive any claims against us regarding the accuracy or completeness of our content.

Let's Stay Connected!

Get insights on healthy living, CBD news, and the latest deals.

Subscription Form
*By signing up via email, you agree to receive marketing messages e.g. promos, cart reminders) from Nesa’s Hemp LLC. Consent is not a condition of purchase. Unsubscribe at any time by clicking the unsubscribe link (where available)
This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A doctor’s advice should be sought before using this and any supplemental dietary product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Void where prohibited by law.
usercrossmenucheckmark-circle linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram