Updated on March 20, 2024

Is CBD addictive?

Fact Checked

Key takeaways

  • CBD alone is not addictive but CBD compounds containing THC may produce withdrawal symptoms.
  • CBD exhibits no effects that lead to abuse or dependence.
  • CBD produces its effects by interacting with endocannabinoid and non-endocannabinoid receptors.
  • Just like a healthy diet, daily use of CBD may promote overall well being.

CBD and THC are distant cousins that produce different effects on users. While THC is highly psychoactive and may lead to addiction, CBD is non-psychoactive. It is often utilized to modulate the psychoactive effects of THC. In this article, we will explore some commonly asked questions about CBD and its nature.

IS CBD addictive?

According to current scientific understanding, CBD is not considered addictive. Unlike its counterpart, THC, which is another compound found in cannabis, CBD does not produce psychoactive effects or a "high." Additionally, CBD does not appear to have the same potential for abuse or dependence as THC.

The World Health Organization (WHO) has stated that CBD exhibits no effects indicative of any abuse or dependence potential in humans. Moreover, a review published in the journal "Current Drug Safety" in 2014 concluded that CBD's safety profile and lack of psychoactive effects make it an attractive option for further research and potential therapeutic use.

It's important to note that CBD products can vary in terms of their composition and quality. Some CBD products may contain trace amounts of THC, which could potentially lead to positive results in drug tests. However, pure CBD itself is not considered addictive.

How does CBD produce its effect on the body?

CBD interacts with the body through the endocannabinoid system (ECS), a complex cell-signaling system that plays a role in regulating various physiological processes. The ECS is involved in maintaining homeostasis, or balance, within the body. While the exact mechanisms of CBD's actions are still being studied, here is an overview of how CBD is believed to interact with the body:

  1. Interaction with Cannabinoid Receptors:

The ECS consists of cannabinoid receptors, primarily CB1 and CB2 receptors. CB1 receptors are mainly found in the central nervous system, while CB2 receptors are primarily located in the peripheral tissues, especially in the immune system. CBD does not directly bind with these receptors in the same way that THC does hence the reason for its non-additive nature. Instead, it appears to influence the receptors indirectly.

  1. Modulation of Endocannabinoids:

The body naturally produces endocannabinoids, which are molecules that bind to cannabinoid receptors. CBD may influence the activity of endocannabinoids by inhibiting enzymes that break them down, leading to increased levels of endocannabinoids in the system.

  1. Interaction with Non-Cannabinoid Receptors:

CBD also interacts with receptors that are not part of the classical cannabinoid system. For example, it interacts with serotonin receptors, which play a role in mood regulation, and it may affect other receptors involved in pain perception, inflammation, and various physiological processes.

  1. Modulation of Neurotransmitter Release:

CBD may influence the release of neurotransmitters in the brain. It is believed to have a modulating effect on neurotransmitter systems, such as increasing the levels of anandamide, a neurotransmitter associated with feelings of well-being.

  1. Influence on Ion Channels:

CBD can interact with ion channels, such as TRPV1 receptors, which are involved in the perception of pain and temperature. By modulating these channels, CBD may affect pain perception and sensitivity.

Frequently asked Questions

Does CBD produce withdrawal symptoms?

No, CBD does not produce withdrawal symptoms. This may be due to its modulatory nature on different channels in the body. This effect allows CBD to control several processes including the interaction between addictive substances and their receptors.

Is CBD good for daily use?

Just like maintaining a healthy diet and regular exercise, adding CBD to your daily routine yields optimal results. We suggest consistent daily use for at least 21-28 days to allow CBD to accumulate in your body, fostering long-term benefits and achieving desired results.

What not to mix with CBD

CBD may affect the interaction and absorption of certain medications. Medications like those used for treating medical conditions such as liver disease, heart issues and kidney diseases should not be combined with CBD.

Want to Learn More?

  1. Is CBD Oil Use While Pregnant Safe?
  2. How Does CBD Oil Make You Feel: What To Know
  3. Is CBD Legal? Here's What To Know
  4. How To Take Control of Your Mind
  5. How To Finally Quiet Your Mind In 6 Ways


Taylor, L., Crockett, J., Tayo, B., Checketts, D., & Sommerville, K. (2020). Abrupt withdrawal of cannabidiol (CBD): A randomized trial. Epilepsy & Behavior, 104, 106938. https://doi.org/10.1016/j.yebeh.2020.106938

Devinsky, O., Cilio, M. R., Cross, H., Fernandez-Ruiz, J., French, J., Hill, C., Katz, R., Marzo, V. D., Jutras-Aswad, D., Notcutt, W. G., Martinez-Orgado, J., Robson, P. J., Rohrback, B. G., Thiele, E., Whalley, B., & Friedman, D. (2014). Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, 55(6), 791. https://doi.org/10.1111/epi.12631

Spinella, T. C., Bartholomeusz, J., Stewart, S. H., & Barrett, S. P. (2023). Perceptions about THC and CBD effects among adults with and without prior cannabis experience. Addictive Behaviors, 137, 107508. https://doi.org/10.1016/j.addbeh.2022.107508

Cata, R., & Jutras-Aswad, D. (2015). Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence. Substance Abuse: Research and Treatment, 9, 33-38. https://doi.org/10.4137/SART.S25081

Navarrete, F., García-Gutiérrez, M. S., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2021). Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.626010

The content on Nesa's Hemp blog is for educational purposes only. We meticulously research and cite our sources, but advise consulting a professional before making decisions based on our information. We derive our content from reputable studies and publications, but individual circumstances may vary. We cannot guarantee the accuracy or applicability of our content to every situation. Nesa's Hemp blog and its authors are not liable for any loss or inconvenience resulting from reliance on our information. By using our blog, you waive any claims against us regarding the accuracy or completeness of our content.

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